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  • How Colored Tablets and Capsules Are Made: Pharma Machinery & Processes Explained

How Colored Tablets and Capsules Are Made: Pharma Machinery & Processes Explained

1. Wstęp

Pharmaceutical tablet and capsule sometimes come in many different colors. These colors are applied with the using of certain equipment such as tablet coating maszyna. This guide explores the reasons behind the colors, the machinery, processes, and offer key industry insights for manufacturers.

 

Kolorowania kapsułki

 

2. Why Color Matters in Pharma Manufacturing?

Color in pharmaceuticals has significant meaning. Firstly, let’s explore the reasons why color matters in tablet and capsule manufacturing. These tablet capsules colors difference for the key purposes of:

    • Prevent Medication Errors: Color coding differentiates drugs, reducing mix-ups, helping both patients and healthcare providers easily identify drugs and doses.
    • Enhance Brand Recognition: Consistent colors boost brand identity, such as Pfizer’s blue Viagra tablets, which is well known for the color branding.
    • Improve Patient Adherence: Visually appealing pills like color-coated tablets are preferred by patients, improving compliance.
    • Taste Masking: Film coatings with color help mask unpleasant tastes, making pills easier to swallow.
    • Psychological Impact: Colors can influence patientsperceptions (NP., red for stimulants, blue for sleep aids).
    • Zgodność z przepisami: Colors must meet FDA/EU guidelines, ensuring safety and quality control.

 

fda-approved-tablets

 

3. How Are Colored Tablets Made? The Tablet Press and Coating Process

Before getting straight to the tablet coloring process, it’s necessary to understand how the tablets are made from very beginning as each step is tightly connected and influenced with each other.

1) Pre-kompresja: Granulacja & Powder Blending

Active pharmaceutical ingredients (Pszczoła) and excipients are blended to achieve a uniform distribution. This process is typically carried out using granulator machines such as wet granulation machines and fluidized bed granulators, which improve powder flowability and ensure even tablet compression.

 

granulation-machine

 

These granulation equipment offer precise control over moisture content, preventing issues like inconsistent tablet hardness. Proper granulation treatment plays a crucial role in optimizing the tablet press process, leading to high-quality tablet production.

2) Tablet Compression: Utilizing Rotary Tablet Press Machine

Rotary pill tablet press machine compress granules into tablets at high speeds. These machines enable production of various tablet shapes, w tym okrągłe, owalny, and custom forms like heart-shaped tablets.

 

tablet-press-machine

 

Wysokiej jakości automatyczna maszyna do tabletu obrotowego ma jedną funkcję klucza, Funkcja wstępna, które mogą wyeliminować powietrze uwięzione w tablecie, Utrzymanie tabletek mundurowych i wysokiej jakości. Tylko z wysokiej jakości tabletkami możesz osiągnąć doskonałe wyniki powlekania tabletów.

3) Po kompresji: Tabletowa powłoka z filmu dla kolorów i ochrony

Kolorowanki tablet z tabletką jest bardzo powszechna w branży. Automatyczna maszyna do powlekania tabletu może zastosować warstwę ochronną i estetyczną w kontrolowanym procesie:

    • Podkładający: Zapewnia przyczepność między rdzeniem tabletu a powłoką kolorów.
    • Kolorowa powłoka: Wykorzystuje naturalne barwniki lub pigmenty na bazie minerałów, takie jak dwutlenek tytanu w celu nieprzezroczystości i tlenków żelaza dla czerwonych lub żółtych odcieni.
    • Polerowanie: Ostateczna warstwa pszczelego lub kołka poprawia połysk i połykanie.

 

tablet-coating-machine

 

When it comes to tablet film coating, it’s important to focus on making sure even coating, drying efficiency. Modern perforated coating pans help with this by allowing better airflow and precise temperature control.

 

4. How Are Colored Capsules Made? The Capsule Filling and Printing Process

Just like understanding the tablet press process, it is essential to grasp the capsule filling process from the beginning to gain a complete overview of all relevant steps. Here below are some key procedures.

1) Capsule Shell Manufacturing & Coloring

One of raw material for capsule filling is empty capsules, for example gelatin capsules (hard-shells or soft-gels). These capsules are pre-dyed either by mixing liquid dyes with the gelatin solution or by adding powdered pigments. Empty capsules come in two-piece designs for easy filling and customization for the mixing colors of these two parts.

2) Capsule Filling Process

Semi-Automatic capsule fillers or fully automatic capsule filling machines will be used for the production of capsules especially in the pharmaceutical and supplement industries which require large volume production. According to different form of materials, specifically liquid or not liquid, these capsule filling machine can be categorized into:

    • Standard capsule filler machines (commonly used for filling powders, granulki, pellety).
    • Automatic Capsule Liquid Filling machine (generally used for liquid capsules).

 

capsule-filling-machine

 

Taking the standard automatic capsule filler as an example, the whole capsule filling production is going through multiple work stations which include:

    • Capsule Dispensing: Automatically places empty capsules into the mold.
    • Capsule Filling: Precisely fills powder into empty capsules.
    • Capsule Locking: Joins and securely locks the capsule halves together.
    • Capsule Output: Discharges the finished, locked capsules.

3) Capsule Printing for Branding & Compliance

Offset printing and inkjet printing machines apply edible inks, which is non-toxic and generally soy-based), for the purpose of branding or giving the dosage details and anti-counterfeit, such as the dosage information printed on Adderall’s orange capsule medication.

 

5. The Role of Coating & Printing in Tablets Capsules

Beyond shaping and formulation, coating and printing add essential functionality to tablets and capsules. Let’s explore the key techniques used in coating and printing.

1) Tablet Coating Techniques for Precision Coloring

There are many coated tablets in the market which include film coated tablets, sugar coated tablets and enteric coated tablets, each of them are made with the following coating techniques respectively:

    • Film Coating A thin, polymer-based layer providing color and protection.
    • Sugar Coating A glossy, taste-enhancing layer used in some over-the-counter products.
    • Enteric Coating A specialized coating that prevents breakdown in the stomach, ensuring release in the intestines.

2) Capsule Printing for Identification & Security

    • Inkjet Printing Uses high-speed edible ink application for batch printing.
    • Offset Printing Precise and efficient for large-scale production.
    • Laser Marking Provides permanent identification without ink, reducing counterfeit risks.

3) Key Machinery for Tablet Capsule Production and Coloring

From the material preparation to finished coated tablet or capsules output, the whole process going through the following machines. Let’s take a look for the details of the machine from Jinlu Packing, which is a leading pharmaceutical and packaging machinery supplier from China.

Tablet Press Machinery & Tablet Coating Machines

 

Dry GranulatLub Tabletkarka rotacyjna Tablet Coating Machine
Model RD-GFZL-10 ZP26/40 D RD-HGBY-80
Image granulation-machine high-speed-rotary-tablet-press Continuous-Tablet-Coating
Pojemność Maks. 10 kg/h 260,000 tabletki/h Maks. 64kg/batch
Rozmiar 1000×800×1650mm 820×1,100×1,750mm 1,370×1,030×1,950mm
Specyfikacja Compression Roller Speed: 0-20 r.p.m

Maximum Thrust: 6-8T

– Rozmiar cząstek : 10-80 mesh

Max Diameter: 25mm

Max Pressure: 100 kN

Pre-pressing: 20 kN

Coating Drum Speed: 2-15 r.p.m

Coating Pan Diameter: Φ600
Hot Air Filtration Cleanliness Level: 0.5μm

Cechy No Need for liquids

Maintain material integrity

Pressure real time monitoring

Single-piece waste rejection

Residual powder recycling

Advanced hot air cabinet & exhaust cabinet

High-performance coating Drum

Intelligent temperature measurement

Capsule Filling Machinery & Capsule Coloring Machines

Here below are two recommended machines from Jinlu Packing and one capsule tablet printer from Ackley Machine Corporation.

 

Maszyna do napełniania kapsułek Capsule Polishing Machine Capsule Printing Machine
Model NJP1500D RD-PG-200 Ackley’s Cantilever Tablet and Capsule Printer
Image NJP1500D-capsule-filling-machine Polishing-machine capsule-printing-machine
Pojemność 90,000 szt./godz 4000-7000 pcs/min 250,000 pcs/h
Rozmiar 1490×1260×2150mm 780x820x1550mm /
Specyfikacja Capsule Size: #000, 00, 0, 1, 2, 3, 4, 5

Filling Rage: Moc, granulki, pellety, tabletki

Indexing Box: 100DS

Revolving speed: 2800

Maximum air pressure: 25

Maximum flow: 220

/
Cechy High dosing accuracy with an error of ≤3%.

Internal groove cam, more stable

Modular design, fast mold change in 15 protokół.

Full stainless steel structure.

Brushless motor with variable frequency drive.

Integrated dust suction function, enhances cleanliness and efficiency.

Multi-lane pocket carrier bar feed system.

Adjustable ramp feed angle to optimize machine feed

Safety enclosure with interlocked doors & enclosed beam path.

 

6. What Tablet and Capsule Colors Should Pharmaceutical Manufacturers Use?

Choosing the right tablet and capsule colors is essential for drug differentiation, patient compliance, and branding. So what tablet and capsule colors you shall select for your pharmaceutical production?

1) Functional Colors for Drug Identification

Pharmaceutical companies should align color choices with the intended use and target audience for their products. Na przykład:

    • High-risk medications such as blood thinners) often use bold, easily recognizable colors to prevent errors.
    • Multi-dose regimens may use different colors per dosage strength, such as different color for 5mg, 10mg and 20mg.
    • Pediatric medications typically have bright, Nie instytucjonalne kolory w celu poprawy przestrzegania.

2) Psychologia kolorów & Postrzeganie pacjenta

Różne kolory mogą wpływać na to, jak pacjenci postrzegają skuteczność leków:

 

Kolor Powszechne zastosowania w farmaceutykach Postrzeganie psychologiczne Narkotyki marki
Biały Antybiotyki, Ogólne leki Neutralny, czysty i bezpieczny Amoksycylina

Białe losy amoksycyliny

(Zdjęcie: www.drugs.com)

Czerwony/pomarańczowy Stymulanty, Budy energetyczne, środki przeciwbólowe Energetyzowanie, Przykuwając uwagę Adderall

Adderall-pomarańczowe pigułki

(Zdjęcie: www.drugs.com)

Niebieski/zielony Anty-anxiety, Pomoce snu, leki przeciwdepresyjne Łagodzący, kojący Xanax

Xanax-1-pigułki

(Zdjęcie: www.drugs.com)

Żółty Witaminy, suplementy Wesoły, związane z witalnością Riboflawin

Natureway-Yellow-capsule

(Zdjęcie: www.naturesway.com)

Fioletowy Leki neurologiczne, Marki premium Luksus, innowacja Nexium

Nexium-Pule-Capsules

(Zdjęcie: www.drugs.com)

 

 

3) Zatwierdzone przez regulacyjne barwniki farmaceutyczne

Skorupy kapsułkowe i powłoki tabletowe powinny być sformułowane z nietoksycznym, hipoalergiczny, i stabilne barwniki. All colors used in pharmaceuticals must be FDA or EU-approved and safe for consumption. These include:

    • Synthetic Dyes: FD&C Blue No. 1, FD&C Red No. 40 (vivid colors).
    • Natural Colorants: Carotenoids (yellow-orange), Chlorophyll (green).
    • Mineral-Based Pigments: Titanium dioxide (white), Iron oxides (red, yellow, brown).

 

7. Wniosek

Podsumowując, colored tablets and capsules are created for the purpose of safety, branding, and patient adherence, itp. Choosing the right machine and right colors for your capsule or tablet manufacturing is very essential. This article provides complete guide and insight that can help you to select the right colors and right machine for the colored tablets and capsules production.

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