Le choix de la bonne presse à comprimés est un élément essentiel du processus de fabrication pharmaceutique. Le choix de presse à comprimés n'affecte pas seulement la qualité du produit, mais concerne également l'efficacité de la production et le contrôle des coûts. Surtout avec les progrès continus de la technologie pharmaceutique, choisir le bon équipement est particulièrement important. Dans cet article, nous parlerons des points clés auxquels vous devez prêter attention lors du choix d'une presse à comprimés, et vous trouverez les réponses à toutes les questions que vous vous posez sur le choix d'une presse à comprimés dans l'article suivant.

1. Quelles sont vos exigences de production?

La sélection d'une presse à comprimés doit commencer par vos besoins de production. Capacité de production spécifique, caractéristiques du produit, et les exigences de qualité détermineront le type de machine que vous choisirez.

1.1 Quelle est la demande de production?

Combien de comprimés devez-vous produire par jour? Ce numéro est la base la plus importante pour la sélection de votre presse à comprimés. Si votre ligne de production a un rendement quotidien élevé, vous avez besoin d'une presse à comprimés capable de produire des comprimés rapidement et efficacement, probablement une presse à comprimés rotative à grande vitesse. Alors que pour les petits lots, production multi-espèces ou au stade expérimental, une seule presse à comprimés perforée peut suffire.

1.2 Quelles sont les caractéristiques du produit?

Les spécifications de la tablette et les caractéristiques matérielles du produit affecteront également le choix de l'équipement.. S'il existe différentes spécifications de tablette, vous devez choisir une presse à comprimés avec une forte compatibilité avec les moules. Different material characteristics may also require different parameters such as pressing pressure and speed.

1.3 What are the quality standards?

What are the requirements for tablet weight, hardness, disintegration, etc.. in your production line? These factors directly affect the technical parameters of the equipment. Par exemple, if your tablets have strict requirements for hardness and disintegration time, you need to choose a tablet press with a more adaptable pressure range.

2. What type of tablet press do you need?

There are mainly single punch tablet presses, rotary tablet presses and multi-layer tablet presses available in the market, which have different applications, advantages and disadvantages.

2.1 Presse à comprimés à poinçon unique

Single punch tablet press is the simplest type of tablet pressing equipment, which works by applying pressure in the mold through an upper punch and a lower punch to compress the material filled in the mold into tablets. This type of machine is usually small and easy to operate and is suitable for small batch production on a laboratory scale or for product development in the pilot stage. However, the productivity is relatively low as only one tablet can be pressed at a time.

2.2 Rotary Tablet Press

Le presse à comprimés rotative is the main tablet production equipment in the production line of the pharmaceutical industry today due to its high speed tablet production efficiency, which is characterized by the possibility of using multiple punches to press tablets at the same time. The main structure is that the upper and lower punches are mounted on a turntable, and as the turntable rotates, each punch goes through the processes of powder material filling, material pre-pressing, main pressing into tablets, and tablet discharging. High-efficiency continuous tablet production can be realized by the turntable drive, which greatly improves the efficiency of tablet production. Rotary tablet press is suitable for large-scale industrialized production, and the pressure size and tablet thickness can be adjusted as needed to meet the requirements of different materials.

There are many factors affecting the output of rotary tablet press machine, mainly including the following aspects:

Factors of the equipment itself

Rotary speed: The faster the rotary speed, the more tablets will be produced per unit of time.
Number of Punches: The greater the number of punches, plus le nombre de presses à comprimés simultanées est élevé et plus le rendement est élevé.
Coup de poing: Plus la course du poinçon est longue, plus le temps de pressage du comprimé est long et plus le rendement est faible.

Propriétés des matériaux

Flux de poudre: Meilleur est le débit de poudre, plus l'alimentation est uniforme, plus le processus de comprimés est stable, et plus le rendement est élevé.
Niveaux d'humidité des matériaux: Une teneur en humidité élevée ou faible peut avoir un impact sur la qualité des comprimés., affectant ainsi le rendement final.
Taille des particules: Une distribution granulométrique trop large ou trop fine affectera la qualité des comprimés., la distribution granulométrique est uniforme, la taille des particules est modérée, le meilleur effet des comprimés.
Viscosité du matériau: Une viscosité trop élevée du matériau entraînera facilement le collage du poinçon, ce qui affectera la sortie.

According to different output and tablet size, you can choose different types of tablet presses:

2.3 Multi-Layer Rotary Tablet Press

Multi-layer rotary tablet press is a tablet pressing machine that adds multiple feeders to the rotary tablet press so that it can form multi-layer structure tablets in one pressing process. This technology is mainly used for the manufacture of tablets containing different ingredients or having an extended release effect. In a multilayer rotary tablet press, the material is filled into the mold in a predetermined sequence through different feeders and then compressed in one or more steps to form the final tablet product. Multi-layer tablet compression technology can improve the bioavailability of the drug and control the release rate of the drug to achieve better therapeutic effect.

3. How to choose the level of automation?

A tablet press with a high degree of automation can reduce manual operations, increase productivity and reduce error rates. The automated control system can also help you monitor and adjust the weight, pressure and other parameters of the tablets in real time to ensure the consistency of the product. However, highly automated equipment has a higher initial investment and is suitable for companies with higher production demands.

4. What technical parameters should I look for in a tablet press?

When choosing a tablet press, the key technical parameters will directly affect the performance and production quality of the equipment. You need to consider the following aspects according to the requirements of the tablet production process, the nature of raw materials, the size of the production scale and other needs:

4.1 Is the pressure sufficient?

The tabletting process requires different pressure ranges for different materials and tablets. The maximum and minimum pressures of the equipment must be in accordance with the characteristics of your material, otherwise it may result in substandard tablet hardness or disintegration time. Therefore, before making a purchase, be sure to check whether the pressure range of the equipment can meet your production needs.

4.2 Is the speed fast enough?

The tablet pressing speed of the equipment directly affects the production efficiency, which is usually measured by the number of tablets pressed per minute. If you have a large production load, you need to consider choosing a high capacity machine. Rotary tablet presses are faster due to their ability to press tablets at multiple stations simultaneously, while single-punch tablet presses are suitable for a lower production tempo.

4.3 What about mold compatibility?

If your production line needs to produce tablets of many different shapes and sizes, die compatibility will be the deciding factor. Choosing a tablet press that can accommodate a wide range of dies will help you reduce die changeover time and increase production flexibility.

5. Reliability of the equipment, can you rest assured?

The stability and reliability of a tablet press is an important factor in guaranteeing the quality of the tablets produced. Choosing a reliable machine can help you to produce high quality and stable tablet products, and moreover, it can reduce the failure and downtime, so as to improve the production efficiency.

5.1 Is brand important?

Choosing a tablet press brand with a good reputation usually means higher quality equipment and better after-sales service. Well-known manufacturers usually offer longer warranty periods and faster technical support so that you can get your equipment problems solved in a timely manner.

5.2 What about after-sales service?

Prompt after-sales service can reduce downtime due to equipment failure. You need to make sure that the manufacturer can provide sufficient supply of spare parts and technical support to ensure the long-term stable operation of the equipment.

5.3 Is maintenance costly?

When using a tablet press for a long period of time, the maintenance cost is a key consideration for you. Certain equipment, although less expensive to purchase, may not be cost-effective to use in the long run if the maintenance cost is high. Therefore, it is important to know how often and how much the equipment will cost to maintain before purchasing.

6. Importance of GMP compliance

Compliance of tablet press with GMP is an important guarantee to ensure the quality of drugs, meet regulatory requirements and enhance corporate image. It is a series of quality management norms that must be strictly adhered to in the process of drug production.

6.1 Does the equipment comply with GMP standards?

GMP standards require equipment to be designed with the ability to prevent contamination, such as dustproof design during tablet pressing. This not only ensures the quality of your drug product, but also saves you time in cleaning and maintenance.

6.2 Are the equipment materials safe?

Components that come into contact with pharmaceuticals should be made of stainless steel that meets food-grade or pharmaceutical-grade standards to ensure the safety of pharmaceuticals and compliance with relevant pharmaceutical regulatory standards.

Choosing the right tablet press is a systematic process that takes into account production requirements, equipment type, technical parameters, equipment reliability and compliance with industry standards. Multi-layer tabletting technology brings more possibilities to the pharmaceutical industry, but it also puts higher demands on the equipment. For more information about Tablet Press Machine, please contact us, we will provide you with detailed program.