Seleccionar la presión de la tableta derecha es una parte vital del proceso de fabricación farmacéutica. La elección de prensa de tabletas no solo afecta la calidad del producto, pero también se relaciona con la eficiencia de producción y el control de costos. Especialmente con el progreso continuo de la tecnología farmacéutica, Elegir el equipo correcto es especialmente importante. En este artículo, Hablaremos sobre los puntos clave a los que debe prestar atención al elegir una tableta Presione, y encontrará las respuestas a todas las preguntas que tiene en mente sobre elegir una tableta Press en el siguiente artículo..

1. ¿Cuáles son sus requisitos de producción??

La selección de una prensa de tableta debe comenzar con sus necesidades de producción.. Capacidad de producción específica, Características del producto, and quality requirements will determine the type of machine you choose.

1.1 What is the demand for production?

How many tablets do you need to produce per day? This number is the most important basis for your tablet press selection. If your production line has a high daily output, you need a tablet press that can produce tablets quickly and efficiently, probably a high-speed rotary tablet press. Whereas for small batch, multi-species production or at the experimental stage, a single punch tablet press may be sufficient.

1.2 What are the characteristics of the product?

The tablet specification and material characteristics of the product will also affect the choice of equipment. If there are various tablet specifications, you need to choose a tablet press with strong mold compatibility. Different material characteristics may also require different parameters such as pressing pressure and speed.

1.3 What are the quality standards?

What are the requirements for tablet weight, dureza, disintegration, etc.. in your production line? These factors directly affect the technical parameters of the equipment. Por ejemplo, if your tablets have strict requirements for hardness and disintegration time, you need to choose a tablet press with a more adaptable pressure range.

2. What type of tablet press do you need?

There are mainly single punch tablet presses, rotary tablet presses and multi-layer tablet presses available in the market, which have different applications, advantages and disadvantages.

2.1 Prensa de tabletas de un solo punzón

Single punch tablet press is the simplest type of tablet pressing equipment, que funciona aplicando presión en el molde a través de un golpe superior y un golpe inferior para comprimir el material relleno en el molde en tabletas. Este tipo de máquina suele ser pequeño y fácil de operar y es adecuado para la producción de lotes pequeños a escala de laboratorio o para el desarrollo de productos en la etapa piloto. Sin embargo, La productividad es relativamente baja ya que solo se puede presionar una tableta a la vez.

2.2 Prensa rotatoria para tabletas

El prensa rotatoria de tabletas es el principal equipo de producción de tabletas en la línea de producción de la industria farmacéutica hoy debido a su eficiencia de producción de tabletas de alta velocidad, que se caracteriza por la posibilidad de usar múltiples golpes para presionar tabletas al mismo tiempo. La estructura principal es que los golpes superiores e inferiores están montados en un plato giratorio, y a medida que gira el plato giratorio, Cada golpe atraviesa los procesos de relleno de material en polvo, prensación de materiales, Principal presionando en tabletas, y descarga de tabletas. La producción de tabletas continua de alta eficiencia puede ser realizada por la unidad de giraduras, lo que mejora enormemente la eficiencia de la producción de tabletas. Rotary Tablet Press es adecuada para la producción industrializada a gran escala, y el tamaño de presión y el grosor de la tableta se pueden ajustar según sea necesario para cumplir con los requisitos de diferentes materiales.

Hay muchos factores que afectan la salida de la máquina de prensa de tableta rotaria, principalmente incluir los siguientes aspectos:

Factores del equipo en sí

Velocidad giratoria: Cuanto más rápido sea la velocidad giratoria, Cuantas más tabletas se producirán por unidad de tiempo.
Número de golpes: Cuanto mayor sea el número de golpes, the greater the number of simultaneous tablet presses and the higher the output.
Punch Stroke: The longer the punch stroke, the longer the tablet pressing time and the lower the output.

Propiedades del material

Powder Flow: The better the powder flow, the more uniform the feed, the more stable the tabletting process, and the higher the output.
Material moisture levels: Both high and low moisture content can impact the quality of the tablets, thereby affecting the final yield.
Particle size: Particle size distribution is too wide or too fine will affect the quality of tablets, particle size distribution is uniform, particle size is moderate, the best effect of tablets.
Material Viscosity: Too much material viscosity will easily lead to the sticking of the punch, which will affect the output.

According to different output and tablet size, you can choose different types of tablet presses:

2.3 Multi-Layer Rotary Tablet Press

Multi-layer rotary tablet press is a tablet pressing machine that adds multiple feeders to the rotary tablet press so that it can form multi-layer structure tablets in one pressing process. This technology is mainly used for the manufacture of tablets containing different ingredients or having an extended release effect. In a multilayer rotary tablet press, the material is filled into the mold in a predetermined sequence through different feeders and then compressed in one or more steps to form the final tablet product. Multi-layer tablet compression technology can improve the bioavailability of the drug and control the release rate of the drug to achieve better therapeutic effect.

3. How to choose the level of automation?

A tablet press with a high degree of automation can reduce manual operations, increase productivity and reduce error rates. The automated control system can also help you monitor and adjust the weight, pressure and other parameters of the tablets in real time to ensure the consistency of the product. Sin embargo, highly automated equipment has a higher initial investment and is suitable for companies with higher production demands.

4. What technical parameters should I look for in a tablet press?

When choosing a tablet press, Los parámetros técnicos clave afectarán directamente el rendimiento y la calidad de producción del equipo.. Debe considerar los siguientes aspectos de acuerdo con los requisitos del proceso de producción de tabletas., la naturaleza de las materias primas, el tamaño de la escala de producción y otras necesidades:

4.1 ¿Es la presión suficiente??

El proceso de mesa requiere diferentes rangos de presión para diferentes materiales y tabletas.. Las presiones máximas y mínimas del equipo deben estar de acuerdo con las características de su material., de lo contrario, puede dar lugar a la dureza o el tiempo de desintegración de la tableta. Por lo tanto, Antes de hacer una compra, Asegúrese de verificar si el rango de presión del equipo puede satisfacer sus necesidades de producción.

4.2 ¿Es la velocidad lo suficientemente rápida??

The tablet pressing speed of the equipment directly affects the production efficiency, which is usually measured by the number of tablets pressed per minute. If you have a large production load, you need to consider choosing a high capacity machine. Rotary tablet presses are faster due to their ability to press tablets at multiple stations simultaneously, while single-punch tablet presses are suitable for a lower production tempo.

4.3 What about mold compatibility?

If your production line needs to produce tablets of many different shapes and sizes, die compatibility will be the deciding factor. Choosing a tablet press that can accommodate a wide range of dies will help you reduce die changeover time and increase production flexibility.

5. Reliability of the equipment, can you rest assured?

The stability and reliability of a tablet press is an important factor in guaranteeing the quality of the tablets produced. Choosing a reliable machine can help you to produce high quality and stable tablet products, and moreover, it can reduce the failure and downtime, so as to improve the production efficiency.

5.1 Is brand important?

Choosing a tablet press brand with a good reputation usually means higher quality equipment and better after-sales service. Well-known manufacturers usually offer longer warranty periods and faster technical support so that you can get your equipment problems solved in a timely manner.

5.2 What about after-sales service?

Prompt after-sales service can reduce downtime due to equipment failure. You need to make sure that the manufacturer can provide sufficient supply of spare parts and technical support to ensure the long-term stable operation of the equipment.

5.3 Is maintenance costly?

When using a tablet press for a long period of time, the maintenance cost is a key consideration for you. Certain equipment, although less expensive to purchase, may not be cost-effective to use in the long run if the maintenance cost is high. Por lo tanto, it is important to know how often and how much the equipment will cost to maintain before purchasing.

6. Importance of GMP compliance

Compliance of tablet press with GMP is an important guarantee to ensure the quality of drugs, meet regulatory requirements and enhance corporate image. It is a series of quality management norms that must be strictly adhered to in the process of drug production.

6.1 Does the equipment comply with GMP standards?

GMP standards require equipment to be designed with the ability to prevent contamination, such as dustproof design during tablet pressing. This not only ensures the quality of your drug product, but also saves you time in cleaning and maintenance.

6.2 Are the equipment materials safe?

Components that come into contact with pharmaceuticals should be made of stainless steel that meets food-grade or pharmaceutical-grade standards to ensure the safety of pharmaceuticals and compliance with relevant pharmaceutical regulatory standards.

Choosing the right tablet press is a systematic process that takes into account production requirements, equipment type, technical parameters, equipment reliability and compliance with industry standards. Multi-layer tabletting technology brings more possibilities to the pharmaceutical industry, but it also puts higher demands on the equipment. For more information about Tablet Press Machine, please contáctanos, we will provide you with detailed program.