Selecting the right tablet press is a vital part of the pharmaceutical manufacturing process. The choice of πρέσα tablet not only affects the quality of the product, but also relates to production efficiency and cost control. Especially with the continuous progress of pharmaceutical technology, choosing the right equipment is especially important. Σε αυτό το άρθρο, we will talk about the key points that you need to pay attention to when choosing a tablet press, and you will find the answers to all the questions you have in your mind about choosing a tablet press in the following article.

1. What are your production requirements?

The selection of a tablet press should start from your production needs. Specific production capacity, product characteristics, and quality requirements will determine the type of machine you choose.

1.1 What is the demand for production?

How many tablets do you need to produce per day? This number is the most important basis for your tablet press selection. If your production line has a high daily output, you need a tablet press that can produce tablets quickly and efficiently, probably a high-speed rotary tablet press. Whereas for small batch, multi-species production or at the experimental stage, a single punch tablet press may be sufficient.

1.2 What are the characteristics of the product?

The tablet specification and material characteristics of the product will also affect the choice of equipment. If there are various tablet specifications, you need to choose a tablet press with strong mold compatibility. Διαφορετικά χαρακτηριστικά υλικού μπορεί επίσης να απαιτούν διαφορετικές παραμέτρους όπως πίεση και ταχύτητα πίεσης.

1.3 Ποια είναι τα πρότυπα ποιότητας?

Ποιες είναι οι απαιτήσεις για το βάρος του tablet, σκληρότητα, αποσύνθεση, και τα λοιπά. στη γραμμή παραγωγής σας? Αυτοί οι παράγοντες επηρεάζουν άμεσα τις τεχνικές παραμέτρους του εξοπλισμού. Για παράδειγμα, εάν τα δισκία σας έχουν αυστηρές απαιτήσεις για σκληρότητα και χρόνο αποσύνθεσης, πρέπει να επιλέξετε μια πρέσα tablet με πιο προσαρμόσιμο εύρος πίεσης.

2. Τι τύπο πρέσας tablet χρειάζεστε?

Υπάρχουν κυρίως πρέσες ταμπλετών μονής διάτρησης, περιστροφικές πρέσες ταμπλετών και πρέσες ταμπλετών πολλαπλών στρώσεων που διατίθενται στην αγορά, που έχουν διαφορετικές εφαρμογές, πλεονεκτήματα και μειονεκτήματα.

2.1 Πρέσα Tablet Single Punch

Η πρέσα ταμπλετών μονής διάτρησης είναι ο απλούστερος τύπος εξοπλισμού συμπίεσης tablet, which works by applying pressure in the mold through an upper punch and a lower punch to compress the material filled in the mold into tablets. This type of machine is usually small and easy to operate and is suitable for small batch production on a laboratory scale or for product development in the pilot stage. Ωστόσο, the productivity is relatively low as only one tablet can be pressed at a time.

2.2 Περιστροφική πρέσα ταμπλετών

Ο rotary tablet press is the main tablet production equipment in the production line of the pharmaceutical industry today due to its high speed tablet production efficiency, which is characterized by the possibility of using multiple punches to press tablets at the same time. The main structure is that the upper and lower punches are mounted on a turntable, and as the turntable rotates, each punch goes through the processes of powder material filling, material pre-pressing, main pressing into tablets, and tablet discharging. High-efficiency continuous tablet production can be realized by the turntable drive, which greatly improves the efficiency of tablet production. Rotary tablet press is suitable for large-scale industrialized production, and the pressure size and tablet thickness can be adjusted as needed to meet the requirements of different materials.

There are many factors affecting the output of rotary tablet press machine, mainly including the following aspects:

Factors of the equipment itself

Rotary speed: The faster the rotary speed, the more tablets will be produced per unit of time.
Number of Punches: The greater the number of punches, the greater the number of simultaneous tablet presses and the higher the output.
Punch Stroke: The longer the punch stroke, the longer the tablet pressing time and the lower the output.

Material Properties

Powder Flow: The better the powder flow, the more uniform the feed, the more stable the tabletting process, and the higher the output.
Material moisture levels: Both high and low moisture content can impact the quality of the tablets, thereby affecting the final yield.
Particle size: Particle size distribution is too wide or too fine will affect the quality of tablets, particle size distribution is uniform, particle size is moderate, the best effect of tablets.
Material Viscosity: Too much material viscosity will easily lead to the sticking of the punch, which will affect the output.

Ανάλογα με τη διαφορετική έξοδο και το μέγεθος του tablet, μπορείτε να επιλέξετε διαφορετικούς τύπους πρέσες tablet:

2.3 Περιστροφική πρέσα ταμπλετών πολλαπλών στρώσεων

Περιστροφική πρέσα ταμπλετών πολλαπλών στρώσεων είναι μια μηχανή συμπίεσης ταμπλετών που προσθέτει πολλαπλούς τροφοδότες στην περιστροφική πρέσα ταμπλετών έτσι ώστε να μπορεί να σχηματίσει ταμπλέτες πολλαπλών στρώσεων σε μια διαδικασία συμπίεσης. Αυτή η τεχνολογία χρησιμοποιείται κυρίως για την κατασκευή δισκίων που περιέχουν διαφορετικά συστατικά ή έχουν αποτέλεσμα παρατεταμένης αποδέσμευσης. Σε πολυστρωματική περιστροφική πρέσα ταμπλετών, το υλικό γεμίζεται στο καλούπι με μια προκαθορισμένη σειρά μέσω διαφορετικών τροφοδοτικών και στη συνέχεια συμπιέζεται σε ένα ή περισσότερα βήματα για να σχηματιστεί το τελικό προϊόν δισκίου. Multi-layer tablet compression technology can improve the bioavailability of the drug and control the release rate of the drug to achieve better therapeutic effect.

3. How to choose the level of automation?

A tablet press with a high degree of automation can reduce manual operations, increase productivity and reduce error rates. The automated control system can also help you monitor and adjust the weight, pressure and other parameters of the tablets in real time to ensure the consistency of the product. Ωστόσο, highly automated equipment has a higher initial investment and is suitable for companies with higher production demands.

4. What technical parameters should I look for in a tablet press?

When choosing a tablet press, οι βασικές τεχνικές παράμετροι θα επηρεάσουν άμεσα την απόδοση και την ποιότητα παραγωγής του εξοπλισμού. Πρέπει να λάβετε υπόψη τις ακόλουθες πτυχές σύμφωνα με τις απαιτήσεις της διαδικασίας παραγωγής tablet, τη φύση των πρώτων υλών, το μέγεθος της κλίμακας παραγωγής και άλλες ανάγκες:

4.1 Είναι επαρκής η πίεση?

Η διαδικασία δισκιοποίησης απαιτεί διαφορετικά εύρη πίεσης για διαφορετικά υλικά και ταμπλέτες. Οι μέγιστες και ελάχιστες πιέσεις του εξοπλισμού πρέπει να είναι σύμφωνες με τα χαρακτηριστικά του υλικού σας, Διαφορετικά, μπορεί να οδηγήσει σε υποτυπώδη σκληρότητα ή χρόνο αποσύνθεσης του δισκίου. Επομένως, πριν κάνετε μια αγορά, φροντίστε να ελέγξετε εάν το εύρος πίεσης του εξοπλισμού μπορεί να καλύψει τις ανάγκες παραγωγής σας.

4.2 Είναι η ταχύτητα αρκετά γρήγορη?

The tablet pressing speed of the equipment directly affects the production efficiency, which is usually measured by the number of tablets pressed per minute. If you have a large production load, you need to consider choosing a high capacity machine. Rotary tablet presses are faster due to their ability to press tablets at multiple stations simultaneously, while single-punch tablet presses are suitable for a lower production tempo.

4.3 What about mold compatibility?

If your production line needs to produce tablets of many different shapes and sizes, die compatibility will be the deciding factor. Choosing a tablet press that can accommodate a wide range of dies will help you reduce die changeover time and increase production flexibility.

5. Reliability of the equipment, can you rest assured?

The stability and reliability of a tablet press is an important factor in guaranteeing the quality of the tablets produced. Choosing a reliable machine can help you to produce high quality and stable tablet products, and moreover, it can reduce the failure and downtime, so as to improve the production efficiency.

5.1 Is brand important?

Choosing a tablet press brand with a good reputation usually means higher quality equipment and better after-sales service. Well-known manufacturers usually offer longer warranty periods and faster technical support so that you can get your equipment problems solved in a timely manner.

5.2 What about after-sales service?

Prompt after-sales service can reduce downtime due to equipment failure. You need to make sure that the manufacturer can provide sufficient supply of spare parts and technical support to ensure the long-term stable operation of the equipment.

5.3 Is maintenance costly?

When using a tablet press for a long period of time, the maintenance cost is a key consideration for you. Certain equipment, although less expensive to purchase, may not be cost-effective to use in the long run if the maintenance cost is high. Επομένως, it is important to know how often and how much the equipment will cost to maintain before purchasing.

6. Importance of GMP compliance

Compliance of tablet press with GMP is an important guarantee to ensure the quality of drugs, meet regulatory requirements and enhance corporate image. It is a series of quality management norms that must be strictly adhered to in the process of drug production.

6.1 Does the equipment comply with GMP standards?

GMP standards require equipment to be designed with the ability to prevent contamination, such as dustproof design during tablet pressing. This not only ensures the quality of your drug product, but also saves you time in cleaning and maintenance.

6.2 Are the equipment materials safe?

Components that come into contact with pharmaceuticals should be made of stainless steel that meets food-grade or pharmaceutical-grade standards to ensure the safety of pharmaceuticals and compliance with relevant pharmaceutical regulatory standards.

Choosing the right tablet press is a systematic process that takes into account production requirements, equipment type, technical parameters, equipment reliability and compliance with industry standards. Multi-layer tabletting technology brings more possibilities to the pharmaceutical industry, but it also puts higher demands on the equipment. For more information about Tablet Press Machine, please contact us, we will provide you with detailed program.